HHV-6 infections can asymptomatically occur early in life with lifelong persistence. Primary infection with HHV-6 causes roseola infantum, a common childhood disease that resolves spontaneously. The virus remains latent in lymphocytes and monocytes and persists at low levels in cells and tissues. It can reactivate at a later date, and is believed to contribute to diseases of the bone marrow and/or central nervous system in some patients, including mononucleosis like illness with fever, lymphadenopathy, hepatitis, fatal encephalitis, chronic fatigue syndrome, and possibly multiple sclerosis. Transmission of HHV-6 is believed to occur as a result of exposure to saliva.
- Blood samples (serum, plasma)
- Scrapings of epithelial cells
- Prostatic fluid
- Whole blood,
- Leukocytic mass
- FAM (495 – 520 nm) for Internal Control (IC)
- ROX (575 – 602 nm) for HHV-6 DNA